Fowl Pox, is a mild to severe, slow developing disease of birds, caused by viruses of the genus Avipoxvirus (family: Poxviridae). The disease, that bears economic importance in domestic poultry, is primarily apparent in either cutaneous (“dry”) or diphtheritic (“wet”) forms. The cutaneous form of the disease is mild, typically characterized by nodular cutaneous lesions on non-feathered areas of the skin (comb, wattle, face and legs) and more atypically as feather folliculitis in the feathered skin. It appears to be spread by direct contact (including pecking and scratching), by inhalation or ingestion of dust or aerosols, or mechanically by biting insects. Inhalation/ingestion of virus-infected droplets/dust can lead to a more severe infection of the oropharyngeal cavity, called “diphtheritic infections”. The latter is characterized by fibronecrotic, proliferative lesions on the mucous membranes of the upper respiratory tract, mouth and esophagus. Active immunity develops following natural infection or after immunization with live vaccines.