Avian reovirus (ARV) is an ubiquitous poultry pathogen that has been taxonomically classified as a member of the family Reoviridae, subfamily Spinareovirinae, genus Orthoreovirus. In meat-type chickens, ARV infections have a wide range of clinical outcomes and this virus is associated with a variety of syndromes such as viral arthritis (VA) and runting-stunting syndrome (RSS). In the case of VA, pathogenic ARVs replicate in the joints of broiler chickens leading to marked edema and rupture of tendons leading to poor growth, low uniformity, secondary infections, mortality, and downgrading of the carcasses at the processing plant. Traditionally, VA has been controlled by vaccination of the parent stock using live-modified and inactivated vaccines.