Vir 222


Freeze Dried Combined Live Vaccine – Newcastle Disease (VH strain) & Infectious Bronchitis
(Var II 1494 strain) – SPF origin

Newcastle Disease

Newcastle disease (ND) is an acute viral disease of domestic poultry and many other bird species. ND is caused by viruses in the serotype Avian ParaMyxoVirus type 1 (APMV-1). It is a worldwide problem that ranges clinically from inapparent to a rapidly fatal condition, that is characterized by gastrointestinal, respiratory and/or nervous signs. The many ND virus strains vary widely in virulence and tissue tropisms. The presence of virulent strains in poultry requires monitoring and control measures and it severely impacts commercial productivity and international trade in poultry and poultry products. Both attenuated live and inactivated vaccines are used to control the disease. Infectious Bronchitis: Infectious Bronchitis (IB) is an acute, highly contagious respiratory disease of chickens with a worldwide distribution. The disease is caused by the Infectious Bronchitis Virus (IBV), a member of the genus Coronavirus (family: Coronaviridae). With time, several different serotypes of IB viruses have been described, with varying extent of extra-tropism to non-respiratory epithelia (e.g., gut, kidneys and gonads), where they replicate and cause pathologies. To control the disease, live and inactivated vaccines of various serotypes are in use.

Additional information


Each dose contains live Newcastle Disease virus, lentogenic VH strain, at least 106.5 EID50 and live attenuated Infectious Bronchitis virus, 1494 strain, at least 10 3.5EID50.


Active immunization of chickens against Newcastle Disease and Infectious Bronchitis.

Indications for use

Use by instructions of a veterinarian.
Use immediately after reconstitution with antiseptic or disinfectant free drinking water.

Administration and dosage

• Prepare for each 1,000 doses 100-300 ml of non chlorinated water.
• Add the reconstituted vaccine to the adequate volume of spraying water, immediately prior to use, and mix well.
• The ventilation system of the poultry house should be inoperative during the spray/aerosol administration.
• Direct the stream from the sprayer over the heads of the birds.
• Spray at one day of age in delivery boxes:
The volume applied must be accurately determined and repeatable for every box and can range from 7ml to 20ml per 100 birds depending upon the particular spray equipment in use. Droplets of 100-300μm diameter are ideal as they facilitate even coverage of birds.
Drinking water:
• Make sure that drinking water is free of any traces of disinfectants.
• Deprive the birds of drinking water two hours before vaccination.
• Prepare adequate volume of drinking water to be consumed within one to two hours.
• Protect the dissolved vaccine from chlorine by adding BIOVAC'S Blue Neutrachlor® (following the instructions) or skim milk powder (50g/20L) or skim milk (0.5L/20L) to drinking water.
• Stir well after mixing and allow solution to stand for 20 min before adding the vaccine.
• Mix well the reconstituted vaccine in the final volume of disinfectant-free drinking water.
• Let the birds consume all the vaccine-water volume before renewing water supply.
Ocular route:
The vaccine should be dissolved in physiological saline solution (usually 40 ml per 1,000 doses) and administered by means of a standardized dropper. Administer one drop (0.04 ml) of vaccine into the open eye of each bird.


• Vaccinate healthy birds only.
• Use entire contents of the vial when first opened.
• Destroy unused contents and decontaminate empty vials before discarding them.
• Keep vaccination records including vaccine batch number.

Withdrawal period



Store at 2ºC-8ºC, protected from direct sunlight.


Each box contains10 of 1,000, 2,500 or 5,000 doses.


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